[DOI] [PubMed] [Google Scholar] Abyzov A
Given the comparable efficacy of the 3 and 30 nmol/kg doses, the lower dose was chosen for further studies [2]
Our experience shows that this is where protocols can get sloppy
While biotin deficiency is relatively uncommon, individuals with certain metabolic conditions, those taking long-term medications such as anticonvulsants, or patients with poor nutritional absorption may benefit from intramuscular administration
However, those with specific autoimmune conditions (particularly psoriasis or rosacea, where LL-37 is naturally overexpressed locally) should consult with their healthcare provider, as adding exogenous LL-37 could potentially exacerbate hyper-immune responses in those highly specific contexts
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